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Neuroferritinopathy

1 OMIM reference -
1 associated gene
17 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3

Huntington disease

1 OMIM reference -
1 associated gene
8 signs/symptoms

Neuroferritinopathy

Huntington disease

(UniProt - OMIM)

(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FTL	(0.63)	HTT

Citations in the biomedical literature:

Neuroferritinopathy		Huntington disease
	Synonym(s): - Adult basal ganglia disease - Ferritin-related neurodegeneration - Hereditary ferritinopathy		Synonym(s): - Huntington chorea

	Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: elderly Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: variable Average age of death: any age Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C548080		External references: 1 OMIM reference - 1 MeSH reference: D006816


COMMON SIGNS	- Autosomal dominant inheritance - Hypertonia / spasticity / rigidity / stiffness - Psychic / psychomotor regression / dementia / intellectual decline

Neuroferritinopathy		Huntington disease
	Very frequent - Ataxia / incoordination / trouble of the equilibrium - Chorea / athetosis / choreoathetosis / choreic syndrome - Dystonia / torticollis / writer's cramp / blepharospasms Frequent - Abnormal eye movements / oculomotor disorder - Abnormal gait - Execution movement disorder / dysmetria / bradykinesia / akinesia / apraxia - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Motor deficit / trouble Occasional - Alexia / agraphia / writing / reading troubles - Constipation - Elocution disorders / dysarthria / dysphonia - Hypotension - Obnubilation / coma / lethargia / desorientation - Tremor		Frequent - Abnormal cry / voice / phonation disorder / nasal speech - Cortical atrophy without hydrocephaly / cerebral hemiatrophy / subcortical atrophy - EEG anomalies - Movement disorder - Psychic / behavioural troubles